• Now & Next: Mavupharma
    Now & Next: Mavupharma

    Saurabh Kapure, Vice President, Business Development, USA for Jubilant Biosys, recently sat down with Michael Gallatin, Ph.D., president and co-founder of Mavupharma (Mavu), the drug discovery and development company, to discuss some of the latest developments in the industry and at Mavu. In this Q&A, Dr. Gallatin shares his thoughts about Mavupharma, his role at the company, the evolution of biopharma, drug discovery, development, and the road ahead for the industry with Saurabh.

  • What Clinical Teams Should Know About The Benefits Of Auto-Injectors
    What Clinical Teams Should Know About The Benefits Of Auto-Injectors

    For a host of reasons, auto-injectors are becoming biopharma companies’ delivery method of choice for commercial use and late-stage clinical trials. Auto-injectors ensure that the prescribed dose of medication is delivered fully and completely,making it easier to track compliance in clinical trials.

  • Purposeful Design And Development Of A Next-Generation Single-Use Bioprocess Film
    Purposeful Design And Development Of A Next-Generation Single-Use Bioprocess Film

    Fortem film development is an important investment by GE Healthcare, as it helps meet the industry need for a fully characterized platform film across all bioprocessing applications with supply chain transparency as a focal point. 

  • A Novel Cell-Based Screening Assay For Cholesterol Biosynthetic Pathway Inhibition Using The RapidFire HTMS Platform
    A Novel Cell-Based Screening Assay For Cholesterol Biosynthetic Pathway Inhibition Using The RapidFire HTMS Platform

    A client was exploring the possibility of re-purposing an internal collection of antifungal CYP51A1 inhibitors for targeting cancers. GVK BIO was commissioned to enable the such project. Learn how a CYP51A1 inhibitor screening assay using the RapidFire HTMS method was deemed to be optimized, and screening of client compounds was enabled with an acceptable throughput and in a cost-effective manner. This project then went on to yield high potency compounds for the client which allowed them to further their drug discovery plans.

  • Pharmacokinetic Strategies In CNS Drug Discovery
    Pharmacokinetic Strategies In CNS Drug Discovery

    The failure rate for new drugs targeting important CNS diseases in general have higher failure rates than the other diseases, both preclinically and clinically. Pharmacokinetics of the drug along with the drug delivery mechanisms play an important role in determining the success of new CNS drug because blood-brain barriers (BBB) limit the entry of molecules into the CNS. This paper discusses some successful PK approaches that we have employed in the recent past and may help in CNS targeted drug discovery and development efforts.

  • In Vivo Models And In Vitro Assays For Human RSV Infection - Pre-Clinical Antibody, Small Molecule And Vaccine Development
    In Vivo Models And In Vitro Assays For Human RSV Infection - Pre-Clinical Antibody, Small Molecule And Vaccine Development

    Despite over 50 years of research, there remains no licensed vaccine product and disease due to RSV infection remains an unmet medical need. In vitro & in vivo models for RSV vaccine development can provide a critical component in development of anti-RSV antibodies, small molecules and vaccines. Learn how customized and high quality pre-clinical animal models and ex vivo readouts can support your anti-RSV biologics development from concept all the way to IND.

  • A Highly Reproducible In Vivo Model For Bleomycin-Induced Lung Fibrosis In Mice To Evaluate Drugs For The Treatment Of IPF
    A Highly Reproducible In Vivo Model For Bleomycin-Induced Lung Fibrosis In Mice To Evaluate Drugs For The Treatment Of IPF

    Bleomycin-induced pulmonary fibrosis has been a useful pre-clinical model in several species and is most prevalent in rodent models to evaluate potential prophylactic and therapeutic drugs for IPF. The induction and progression of the disease in rodents is of a short duration, making it a practical model for evaluating test compounds in preclinical research. Major drawbacks for this model have been its mortality rate and inconsistency in the induction of the disease. Access to a large portfolio of in vivo fibrosis models allowed for successful drug testing.

  • Meeting Milestones—And Patient Needs—Through Expedited Delivery Of Phase I Materials
    Meeting Milestones—And Patient Needs—Through Expedited Delivery Of Phase I Materials

    To quickly deliver their product to patients in need, Reneo Pharma teamed up with Thermo Fisher Scientific to take advantage of its Quick to Clinic for Oral Solid Dose program.

  • Securing Bioprocess Film Supply
    Securing Bioprocess Film Supply

    Learn how a partnership built on technical expertise and trust is helping to secure the supply of a single-use film built for bioprocessing.

  • Closed And Semi-Automated Processing Of CAR T Cells
    Closed And Semi-Automated Processing Of CAR T Cells

    Challenges of T cell immunotherapies include the costly manufacturing process relying on lengthy and complex open workflows with high manual labor requirements that influence product variability. This application note describes the details of a robust CAR T cell manufacturing workflow that can be adapted for cGMP compliance in commercial production of CAR T cells.

FEATURED PRODUCTS AND SERVICES

Arcos™ Block Management System Arcos™ Block Management System

Minimize errors, increase productivity and keep your laboratory’s resources focused on what matters most—positive patient outcomes—with the Thermo Scientific™ Arcos™ Block Management System.

Single-Use, Flexible Stirred-Tank Bioreactor System: Xcellerex XDR-10 Single-Use, Flexible Stirred-Tank Bioreactor System: Xcellerex XDR-10

This XDR single-use bioreactor is sized for the benchtop, yet allows smooth scale-up to full production.

ZE5™ Cell Analyzer ZE5™ Cell Analyzer

The ZE5 Cell Analyzer is an innovative new flow cytometer with flexible configurations to meet a broad range of experimental complexities and throughput needs. Whether it’s a low-complexity, or a high-complexity experiment, the ZE5 Analyzer has up to 30 parameters and provides a truly expandable flow cytometer. This flexibility makes the ZE5 Analyzer accessible for novice flow cytometry users yet flexible enough for the most experienced flow cytometry professionals

An Overview of BIOVIA Environmental Health and Safety Solutions An Overview of BIOVIA Environmental Health and Safety Solutions

Organizations need to manage chemicals safely from receipt to disposal along the entire lab-to-plant value chain, ensuring Environmental Health and Safety (EH&S) compliance across the enterprise.

More Shots On Goal Using A Developability Assessment Tool More Shots On Goal Using A Developability Assessment Tool

Data-driven risk assessment enables smart decisions on development strategy.

Chemistry CRO Services Chemistry CRO Services

For over 15 years, GVK BIO has been supporting the chemistry needs of clients in the Pharma, Agrochem and material science space. These services are either provided as “Fee for Service” or “FTE” model. We cater to requirement of clients by providing them Medchem support, Library generation or simple plain Syntheses. Apart from designing small molecules and libraries, highly challenging syntheses and isolation of natural products, steroids, carbohydrates, peptides, macro cycles and nucleosides, is accomplished on a routine basis. The prime objective of our team is to accelerate research and development of our clients by providing them valuable scientific solutions with speed and quality.

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INDUSTRY EVENTS

Lyophilization - An Introduction to the Scientific Principles August 27 - 27, 2019
1pm-2:30pm EST, Online Training
The Top Method Validation Mistakes – And How to Avoid Them September 9 - 9, 2019
1pm-2:30pm EDT, Online Training
Pediatric Clinical Trials: Special Considerations and Requirements September 13 - 13, 2019
1pm-2:30pm EDT, Online Training
Discovery on Target 2019 September 16 - 19, 2019
Boston, MA
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 UPCOMING TRAINING COURSES

Lyophilization - An Introduction to the Scientific Principles August 27 - 27, 2019
1pm-2:30pm EST, Online Training
The Top Method Validation Mistakes – And How to Avoid Them September 9 - 9, 2019
1pm-2:30pm EDT, Online Training
Pediatric Clinical Trials: Special Considerations and Requirements September 13 - 13, 2019
1pm-2:30pm EDT, Online Training
How to Write SOPs That are GCP Compliant and Implementable September 17 - 17, 2019
1pm-2:30pm EDT, Online Training
More Upcoming Courses